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Diffstat (limited to 'gnu/packages/bioinformatics.scm')
| -rw-r--r-- | gnu/packages/bioinformatics.scm | 106 |
1 files changed, 106 insertions, 0 deletions
diff --git a/gnu/packages/bioinformatics.scm b/gnu/packages/bioinformatics.scm index f0c4e7748a..87cf164c1a 100644 --- a/gnu/packages/bioinformatics.scm +++ b/gnu/packages/bioinformatics.scm @@ -5796,6 +5796,49 @@ differential expression based on a model using the negative binomial distribution.") (license license:lgpl3+))) +(define-public r-dexseq + (package + (name "r-dexseq") + (version "1.22.0") + (source + (origin + (method url-fetch) + (uri (bioconductor-uri "DEXSeq" version)) + (sha256 + (base32 + "085aqk1wlzzqcqcqhvz74y099kr2ln5dwdxd3rl6zan806mgwahg")))) + (properties `((upstream-name . "DEXSeq"))) + (build-system r-build-system) + (propagated-inputs + `(("r-annotationdbi" ,r-annotationdbi) + ("r-biobase" ,r-biobase) + ("r-biocgenerics" ,r-biocgenerics) + ("r-biocparallel" ,r-biocparallel) + ("r-biomart" ,r-biomart) + ("r-deseq2" ,r-deseq2) + ("r-genefilter" ,r-genefilter) + ("r-geneplotter" ,r-geneplotter) + ("r-genomicranges" ,r-genomicranges) + ("r-hwriter" ,r-hwriter) + ("r-iranges" ,r-iranges) + ("r-rcolorbrewer" ,r-rcolorbrewer) + ("r-rsamtools" ,r-rsamtools) + ("r-s4vectors" ,r-s4vectors) + ("r-statmod" ,r-statmod) + ("r-stringr" ,r-stringr) + ("r-summarizedexperiment" ,r-summarizedexperiment))) + (home-page "http://bioconductor.org/packages/DEXSeq") + (synopsis "Inference of differential exon usage in RNA-Seq") + (description + "This package is focused on finding differential exon usage using RNA-seq +exon counts between samples with different experimental designs. It provides +functions that allows the user to make the necessary statistical tests based +on a model that uses the negative binomial distribution to estimate the +variance between biological replicates and generalized linear models for +testing. The package also provides functions for the visualization and +exploration of the results.") + (license license:gpl3+))) + (define-public r-annotationforge (package (name "r-annotationforge") @@ -9759,3 +9802,66 @@ such as transcription factor binding sites (ChIP-seq) or regions of open chromatin (DNase-seq). Output can be displayed directly in the UCSC Genome Browser.") (license license:gpl3+)))) + +(define-public bismark + (package + (name "bismark") + (version "0.16.3") + (source + (origin + (method url-fetch) + (uri (string-append "https://github.com/FelixKrueger/Bismark/" + "archive/" version ".tar.gz")) + (file-name (string-append name "-" version ".tar.gz")) + (sha256 + (base32 + "1204i0pa02ll2jn5pnxypkclnskvv7a2nwh5nxhagmhxk9wfv9sq")))) + (build-system perl-build-system) + (arguments + `(#:tests? #f ; there are no tests + #:phases + (modify-phases %standard-phases + (delete 'configure) + (delete 'build) + (replace 'install + (lambda* (#:key outputs #:allow-other-keys) + (let ((bin (string-append (assoc-ref outputs "out") + "/bin")) + (docdir (string-append (assoc-ref outputs "out") + "/share/doc/bismark")) + (docs '("Bismark_User_Guide.pdf" + "RELEASE_NOTES.txt")) + (scripts '("bismark" + "bismark_genome_preparation" + "bismark_methylation_extractor" + "bismark2bedGraph" + "bismark2report" + "coverage2cytosine" + "deduplicate_bismark" + "bismark_sitrep.tpl" + "bam2nuc" + "bismark2summary"))) + (mkdir-p docdir) + (mkdir-p bin) + (for-each (lambda (file) (install-file file bin)) + scripts) + (for-each (lambda (file) (install-file file docdir)) + docs) + #t)))))) + (home-page "http://www.bioinformatics.babraham.ac.uk/projects/bismark/") + (synopsis "Map bisulfite treated sequence reads and analyze methylation") + (description "Bismark is a program to map bisulfite treated sequencing +reads to a genome of interest and perform methylation calls in a single step. +The output can be easily imported into a genome viewer, such as SeqMonk, and +enables a researcher to analyse the methylation levels of their samples +straight away. Its main features are: + +@itemize +@item Bisulfite mapping and methylation calling in one single step +@item Supports single-end and paired-end read alignments +@item Supports ungapped and gapped alignments +@item Alignment seed length, number of mismatches etc are adjustable +@item Output discriminates between cytosine methylation in CpG, CHG + and CHH context +@end itemize\n") + (license license:gpl3+))) |